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KMID : 0606920060140030178
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Biomolecules & Therapeutics
2006 Volume.14 No. 3 p.178 ~ p.182
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Effects of Short-term Treatment of Daidzein, Puerarin, Genistein and Tumerone on Mucin Secretion from Cultured Airway Epithelial Cells
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Heo Ho-Jin
Lee Hyun-Jae
Choi Jae-Sue
Lee Jung-Joon
Kim Yeong-Shik
Kang Sam-Sik
Kim Yun-Hee
Park Yang-Chun
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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In this study, we investigated whether daidzein, puerarin, genistein and (+)-ar-tumerone affect mucin secretion from cultured airway epithelial cells and compared with the inhibitory action of poly-L-lysine (PLL) and the stimulatory action of enosine triphosphate (ATP) on mucin secretion. Confluent primary hamster tracheal surface epithelial (HTSE) cells were etabolically radiolabeled using sup>3Hosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The results were as follows : daidzein, puerarin, genistein and (+)-ar-tumerone did not affect mucin secretion at the highest concentrations (10-3M), during 30 min of treatment period. Basically, this finding suggests that daidzein, puerarin and nistein - 3 components derived from Puerariae Radix - and (+)-ar-tumerone derived from Curcumae Rhizoma might not funciton as a coregulator in arious inflammatory iratory diseases showing mucus hypersecretion, although further studies are needed.
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KEYWORD
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Airway mucin, Daidzein, Puerarin, Genistein, (+)-ar-Tumerne
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